The parasitic disease schistosomiasis is one of the developing world’s worst public health scourges, affecting hundreds of millions of people, yet only a single, limited treatment exists to combat the disease. Researchers at the Morgridge Institute for Research are searching for potential new targets by probing the cellular and developmental biology of its source, the parasitic flatworm Schistosoma. “Understanding how these stem cells drive the development of each life-cycle stage may ultimately help prevent disease transmission,” says senior author Phillip Newmark, Howard Hughes Medical Institute and Morgridge investigator and professor of integrative biology at the University of Wisconsin-Madison (and CMB trainer!) Read the full story by the Morgridge Institute for Research.

CMB trainer and assistant professor of medical microbiology and immunology John-Demian Sauer has been awarded a 2018 Burroughs Wellcome Award for Investigators in the Pathogenesis of Infectious Disease (PATH). The Burroughs Wellcome Fund supports biomedical scientists who are early in their careers and advancing fields in the basic biomedical sciences that are undervalued or underfunded. Read the full UW News story here.

Less than two years after CMB trainer Jacques Galipeau was hired to start the Program for Advanced Cell Therapy at the School of Medicine, PACT has obtained an FDA Investigational New Drug (IND) permit to test a treatment for complications of bone marrow transplant. Read the story from UW News.

A new study from CMB trainer Ophelia Venturelli helps to understand how the microbiome is formed, how it changes over time, and how it is affected by disturbances like antibiotics used to treat illnesses. Read the UW News story here.

Fragile X is a genetic condition that affects one in 4,000 males and one in 6,000 females. It’s linked to variations in the gene that makes a protein called FMRP. Symptoms may include intellectual disability, anxiety, and attention deficit disorder, among others. Up to a third of people with fragile X also have autism. There is no cure.
In a study published this week in the journal Nature Communications, researchers at the University of Wisconsin–Madison showed that the absence of FMRP can unbalance critical molecular processes within adult brain cells and lead to the neural and cognitive changes seen in fragile X. Read the full story (written by CMB alumnus Rup Chakravorty) on UW News.

Congratulations to CMB Trainer, Daniel Amador-Noguez! He has received a 2018 Early Career Research Program Grant from the U.S. Department of Energy’s Office of Science. He is among 84 young faculty nationwide to receive the award, designed to bolster the nation's scientific workforce by providing support to exceptional researchers during the crucial early career years. Read more here.

Photo of Daniel Amador-Noguez

Congratulations to CMB Trainer, Philip Romero, who was the recipient of the 2018 Shaw Scientist Award from the Greater Milwaukee Foundation. The award comes with $200,000 in seed funding to support innovative research approaches and the career development of young investigators. Read the full article from UW News.

Dr. Teresa Compton, former CMB Chair, passed away on May 8, 2018. As a professor at UW-Madison, Dr. Compton built an internationally known research program focused on virus:host interactions. She was extensively engaged in university, national and international service and held multiple campus leadership roles including Chair of the Human Cancer Virology program and Chair of the CMB program. She trained many PhD graduates while running a research laboratory, was awarded several U.S. patents and had over 70 published papers.
Her service will be held at 11am on Friday, May 18, 2018, at the Sequoyah Hills Presbyterian Church in Knoxville, Tenn. More details can be found here.

Extraordinary members of the University of Wisconsin–Madison faculty have been honored during the last year with awards supported by the estate of professor, U.S. senator and UW Regent William F. Vilas (1840-1908). Read the full article on UW News.
Congratulations to CMB Faculty Trainers Audrey Gasch and Chris Hittinger!

Congratulations to CMB Trainer, Robert Landick, on being elected to the American Academy of Arts and Sciences! Those previously recognized by the Academy include Martin Luther King Jr., Charles Darwin, and many more. Read the full article from UW News.

Congratulations to CMB Trainer, Qiang Chang, on being named the new director of the Waisman Center! He will assume the position on July 1. Chang joined the UW-Madison faculty in 2007. His research interests focus on Rett syndrome. Read the full story from UW News here.

CMB Trainer Yoshihiro Kawaoka has identified an influenza virus strain that is lethal and transmissible between ferrets. "This is the first case of a highly pathogenic avian virus that transmits between ferrets and kills them," he says. "That's not good for public health." Read the full story from UW News here.

Need advice on mentoring? Dr. Pamela Kreeger, CMB Trainer, and Dr. Kristyn Masters write about developing a mentor-mentee expectations document. You can read the article here.

The prospect of regenerating bone lost to cancer or trauma is a step closer to the clinic as University of Wisconsin-Madison scientists, including CMB trainer Wan-Ju Li, have identified two proteins found in bone marrow as key regulators of the master cells responsible for making new bone.
To read more of the article, visit: http://news.wisc.edu/uw-scientists-find-key-cues-to-regulate-bone-building-

Five faculty members from UW-Madison, including Ann Palmenberg and David Brow, have been elected Fellows of the American Association for the Advancement of Science (AAAS), the world's largest general scientific society.
Read the full article on the UW-Madison news website.

UW-Madison researchers, including CMB trainers John Kuo, Beth Weaver, and Paul Ahlquist, were honored for their cancer research at the October 30, 2016 Badgers men’s basketball game.
Photo credit: David Stluka, UW Athletics

Congratulations to Ahna Skop, who has been honored with the 2016 UW Distinguished Teaching Award. Dr. Skop received her PhD from the CMB Program in 2000 and is currently an associate professor of genetics and a CMB faculty trainer. Dr. Skop has been a leader in advocating for student diversity and inclusiveness at UW-Madison for more than a decade. 
Read the full article here.

University of Wisconsin-Madison researchers studying monkeys have shown that one infection with Zika virus protects against future infection, though pregnancy may drastically prolong the time the virus stays in the body. The researchers, led by UW-Madison pathology Professor and CMB Trainer David O’Connor, published a study in June in the journal Nature Communications.
Read the full article here.

Phil Newmark, a developmental biologist studying the mysteries of how the body regenerates damaged tissue, joined the Morgridge Institute for Research and the University of Wisconsin–Madison Department of Zoology in fall 2016. He has also been appointed as a CMB trainer and will be bringing a team of about ten researchers to campus, including three new CMB students.
Read the full article here.

CMB faculty, Dave Pagliarini, has received the U.S. government's highest honors for scientists who "show exceptional potential for leadership at the frontiers of scientific knowledge in the 21st century." He is 1 of 105 recipients nationally to receive the Presidential Early Career Award for Scientists and Engineers (PECASE). 
Click here to read more

CMB Faculty, Sean Carroll, who runs the film studio, Tangled Bank, in DC has just won an Emmy. A three part series, Your Inner Fish, airing on PBS in 2014, shows how hidden in every human body is a history of past lives before us.

Click here to read more

Or head here to watch this amazing series

CMB faculty, Ronald Raines, was awarded with the Ralph F. Hirschmann Award in Peptide Chemistry by the American Chemistry Society. Their research found that an interaction, previously discarded, is known to be a stabilizer for proteins and have applications for wound treatment in humans.
To read more, click here to hear more at University of Wisconsin - Madison News

CMB faculty, Dave Pagliarini, has been named as the metabolism director for the Morgridge Institute of Research. Pagliarini comes from the Department of Biochemistry at UW-Madison and is in now in charge of creating a new team of metabolic researchers at Morgridge. 
Follow the link here to read more at University of Wisconsin - Madison News

Attie is unpuzzling the fast growing disease of diabetes. Identifying two genes, Sorcs1 and Tomosyn-2, that have shown insight into the bodies stages of metabolism and offering potential leads for new drugs. His own mother suffering from diabetes gives Attie the motivation to solve this puzzle.
Read the rest of the article here.

Xin Sun, professor of medical genetics, was awarded with the Romnes Faculty Fellowship. This award recognizes exceptional faculty members who have earned tenure within the last six years. Her studies have uncovered the origin of birth defects and traces their progression and contributes to the development of genetic counseling, diagnosis and treatment.
Click here to read more on the article: www.news.wisc.edu/23553

CMB Chair, David Wassarman, and CMB faculty member, Barry Ganetzky are featured in a Badger Herald article that outlines the use of fruit flies to study traumatic brain injury.  Check out the article here: http://badgerherald.com/news/2014/10/27/uw-researchers-look-at-fruit-flies-to-study-traumatic-brain-injury/#.VFI2Nry26X1

A team of University of Wisconsin-Madison researchers is digging into the inner workings of the tiny cellular machines called spliceosomes, which help make all of the proteins our bodies need to function. David Brow, Samuel Butcher, and colleagues have captured images of this machine, revealing details never seen before.
Click here to read the full article.

A team of researchers at the University of Wisconsin-Madison, led by Yoshihiro Kawaoka, identified eight genes from influenza viruses isolated from wild ducks that possessed remarkable genetic similarities to the genes that made up the 1918 pandemic flu virus. 
Click here to read the full article. 

Scientists at the University of Wisconsin Carbone Cancer Center (UWCCC) report that a new class of tumor-targeting agents can seek out and find dozens of solid tumors, even illuminating brain cancer stem cells that resist current treatments.
Click here for the full article. 

CMB Faculty, Chris Hittinger, and his team have confirmed that Saccharomyces eubayanus, a native yeast of Patagonia, is the parent yeast of the hybrid lager yeast used to make lager or cold stored beer.
Click here to read the article featured on University of Wisconsin - Madison News. 



Ann Palmenberg, Professor of biochemistry at UW-Madison and CMB faculty member, and her team, which includes CMB student, Holly Basta, have constructed a three-dimensional model of the pathogen that shows why there is no cure yet for the common cold. Palmenberg and her team have published their findings in the journal Virology.  Check out the article here and learn more! 

For the first time, scientists have transplanted neural cells derived from a monkey's skin into its brain and watched the cells develop into several types of mature brain cells, according to the authors of a new study in Cell Reports, including CMB faculty member Su-Chun Zhang. After six months, the cells looked entirely normal, and were only detectable because they initially were tagged with a fluorescent protein.
Read more here.

 Photo: Jeff Miller, UW Communications

Researchers at the University of Wisconsin Carbone Cancer Center, led by CMB faculty Mark Burkard, have discovered a new form of cell division in human cells. They believe it serves as a natural back-up mechanism during faulty cell division, preventing some cells from going down a path that can lead to cancer.
Check out the full UW news story: http://www.news.wisc.edu/21364

With metabolically engineered microorganisms hungry for levulinic acid rather than sugar, a UW-Madison chemical and biological engineer aims to create more sustainable, cost-effective processes for converting biomass into high-energy-density hydrocarbon fuels. Watch a video about Pfleger's work with next generation biofuels at here.
Read the full article here.

For babies, the trip from the womb to the outside world is a transition from a blank, sterile slate to host for what will eventually be trillions of microscopic organisms. "While that microbial environment in the gut is still developing, the introduction of one of many of the wrong kinds of bacteria may cause a severe immune response," says Douglas Weibel, biochemistry professor at UW-Madison. 
Read the full article here

CMB Faculty Trainer, Doug Weibel

Congratulations to two outstanding new faculty trainers in CMB who were recently named Shaw Scientists by the Greater Milwaukee Foundation!  Both Dr. Mehle and Dr. Pagliarini are currently training CMB grad students in their labs.  Read the full UW news article here: http://www.news.wisc.edu/20736

Dr. Mehle on the left, Dr. Pagliarini on the right.

University of Wisconsin-Madison biochemist Judith Kimble has been selected to serve on President Obama's Committee on the National Medal of Science.
Read more here

On a beautiful summer day in Madison, the Kalejta lab poses for a new lab photo.  What a fun idea!  They study the replication and pathogenesis of the beta-herpesvirus called Human Herpesvirus Type 5 (HHV-5) or Human Cytomegalovirus (HCMV).  More information about their lab can be found  here: http://kalejta.virology.wisc.edu/

A recent article by CALS Communications Program member, Nicole Miller, focuses on the use of Amoeba biotherapy in the Filutowicz lab.  The full article is available on the UW-Madison CALS News page.

CMB faculty trainer and alumni, Grace Boekhoff-Falk is featured for her work on fruit flies and how they detect the sense of smell.  The full article can be found on the UW-Madison School of Medicine and Public Health website.

The research projects in our laboratory are focused on molecular imaging, molecular therapy, and nanotechnology. Molecular medicine is the future of 21st century patient management. Molecular imaging, the visualization, characterization and measurement of biological processes, can play pivotal roles in disease diagnosis, treatment efficacy assessment, drug discovery, and the understanding of fundamental biology.

Interests include HIV/SIV genetics, virology, immunology, and pathogenesis. Lab Website.

The Jorgensen lab uses cell and molecular biology tools to identify genes that are sexually dimorphic during sex differentiation, characterize their functional significance, and finally, understand how they are regulated.  Currently, we are focusing on two genes: steroidogenic factor 1 (Sf1) and Iroquois homeobox factor 3 (Irx3).

The Smith group is an interdisciplinary group of researchers working on the development of novel methods and approaches for the analysis and manipulation of bio-molecules. Major interest areas include biological mass spectrometry, DNA computing, surface chemistry, surface detection methods (fluorescence, surface plasmon resonance), and the analysis of genetic variations.

The research projects in the Raines laboratory are designed to reveal how biological phenomena can be explained with the principles of chemistry. The hypotheses are far-reaching, and testing them requires the use of techniques and ideas from diverse disciplines. This broad/deep training is appropriate for scientists who want to perform innovative and meaningful research at the widening chemistry - biology interface.

Dr. Burkard is interested in targeted therapy directed at protein kinases. His laboratory seeks to link therapies with their targets within cancer cells using genetic tools, and to identify patients whose cancers are most likely to benefit from particular drugs. These studies will be used to inform clinical development of novel agents. Dr. Burkard is part of the breast cancer disease oriented working group.

Why do we get sick? This simple question underpins all research in my laboratory. Our overarching goal is to understand why immune responses sometimes fail to protect us from acute and chronic viral diseases. We study innate and adaptive immune responses to acute and chronic viral infections and the mechanisms viruses have evolved to subvert them. Through our discoveries, we hope to contribute to the campaigns against pandemic influenza and AIDS.