CORE CURRICULUM: MOLECULAR BIOLOGY |
Course Department & Number |
Course Name |
Instructors |
Credits/Semester |
Microbiology/Genetics 607 |
Advanced Microbial Genetics |
Roberts |
3 / Fall
|
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Molecular genetic methods and related aspects of prokaryotic and lower eukaryotic biology, as well as critical analysis of the scientific literature. Approximately two-thirds of the course will focus on prokaryotes and one-third on lower eularyotic microbes. P: Micro 370 or equivalent, Biochem 501 or equivalent, Graduate student or intructors consent. * Note: Students can count towards their CMB Core Requirement either Micro 612 OR Micro 607, but not both.
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Microbiology/Biochemistry/ Genetics 612 |
Prokaryotic Molecular Biology |
Gourse, Landick, Keck |
3 / Fall |
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The course will survey topics in prokaryotic moleuclar biology including transcriptoin, translation, DNA and chromosome structure, regulation of gene expression, replication, recombination, and transposition. The object of the course will be to outline basic paradigms in molecular biology and approaches that are used to solve such problems. In general, the course emphasizes our present understanding of molecular mechanisms obtained from biochemical, structural, and genetic approaches as well as how the information was obtained. Some reading of selected papers from the primary literature will be required. This is not a "methods" course; the details of specific methods will be described only insofar as necessary in order to understand how particular information is obtained. Rather than devotelectures to methods out of context, methodology will be incorporated into the lecutres as individual topics are covered.P: Micro 370 or equivalent and Biochem 501 or equivalent, or instructor's consent. * Note: Students can count towards their CMB Core requirement either Micro 612 OR Micro 607, but not both.
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Microbiology/Oncology/Plant Pathology 640 |
General Virology-Multiplication of Viruses |
Ahlquist, Kalejta
|
3 / Fall |
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Lectures on bacterial and animal viruses, their structures, multiplication, and gentics. P: Intro courses in micro, biohem, and genetics.
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Biochemistry 601 |
Protein and Enzyme Structure and Function |
Rayment, Holden
|
2 / Fall |
The goal of this course is to provide an overview of the properties of proteins. In particular, the course will cover the fundamentals of protein structure and stability, and the role of proteins as catalyst.
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Biochemistry 620/ Pharmacology 620 |
Eukaryotic Molecular Biology |
Ansari, Wassarman |
2 / Spring |
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This course focuses on the basic molecular mechanisms that regulate DNA, RNA, and protein metabolism in eukaryotic organisms. The course is intended for advanced undergraduates and first years graduate students with a firm knowledge of basic biochemistry.
P: Biochemistry 508 or equivalent
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Biochemistry/Genetics 703 |
Topics in Eukaryotic Regulation |
Anderson, Kimble, Wickens, Kennedy
|
2 / Spring |
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Biochemistry 703 focuses on molecular and genetic mechanisms that regulate eukaryotic gene expression and development. The course is intended for first year graduate students with a firm knowledge of basic biochemistry, molecular biology, and molecular genetics.
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CORE CURRICULUM: CELL BIOLOGY
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Course Department & Number
|
Course Name
|
Instructors |
Credits/Semester |
Biochemistry 630/Zoology 630/Pharmacology 630 |
Cellular Signal Transduction Mechanisms |
Martin, Anderson, Miyamoto, Keely, Ruoho
|
3 / Fall |
|
Provides a comprehensive introduction for advanced undergraduates and graduate students to the essential elements of cellular transduction mechanisms that allow signaling from the cell surface to the nucleus. Emphasis is on receptors, second messengers, protein kinase cascades, and the regulation of gene transcription. P: Introductory Biochem (Biohem 504, or 507 and 508) and Cell Biology (Biocore 303 or Zoology 570 or Pathology 750) or consent of intructor.
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Oncology 703 |
Carcinogenesis and Tumor Cell Biology |
Ross, Xu, Bradfield, Alexander, Lambert |
3 / Fall |
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Factors involved in tumor production in humans and experimental animals; biology and biochemistry of neoplasia, both in vivo and in vitro. P: Oncology 401 or equivalent, organic chem, biochem, cell bio, virology, or consent of intructor.
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Pathology 750 |
Cellular and Molecular Biology/Pathology |
Rapraeger |
3 / Spring |
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The emphasis is on our current understanding of molecular and cellular mechanisms. Where possible, human diseases are used to illustrate the outcome at the organismal level of defects in these mechanisms. Lectures will draw from the current research literature and cover topics such as intracellular protein and vesicle sorting, cell cycle, intracellular signaling, cell adhesion, cell migration, and growth. Current papers are discussed during in-class discussion.
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ETHICS COURSES |
Course Department & Number |
Course Name |
Instructors |
Credits/Semester |
Medical History & Bioethics 999 |
Advanced Independent Study, Special Topics: Research Ethics |
Leavitt, Schalick, Lederer
|
1-3 / Fall, Spring - Odd Years |
This course objective is to enable students to understand the policies regulating research at land grant universities and the moral principles on which these policies are based.
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Medical History & Bioethics 545 |
Ethical and Regulatory Issues in Clinical Investigation |
Fost |
1 / Fall
|
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This course will explore and examine the ethical issues central to clinical research, regulations governing clinical investigation, and the role of good clinical practice for clinical trials. Participants who master this course material will be able to think critically about the ethical issues central to clinical research and know the basic elements of the federal regulations affecting clinical investigation.
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Surgical Sciences 812 |
Research Ethics and Career Development |
Bjorling |
2 / Fall |
Agronomy/Medical History & Bioethics 565 |
The Ethics of Modern Biotechnology |
Streiffer |
3 / Spring |
Study of ethical issues arising from the application of modern biotechnology to microorganisms, crops, and non-human animals. Readings cover moral theory, technology studies, political philosophy, the science used in biotechnology, and current regulations governing its use.
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Medical History & Bioethics 558 |
Ethical Problems Raised by Biomedical Technology |
Fagan, Ahlberg |
3 / Spring |
Ethical issues apparently created by new biomedical technologies, such as genetic screening, prenatal diagnosis, prolongation of life, treatment of severe birth defects, in vitro fertilization, behavior modification, psychosurgery, and transplantation.
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Oncology 675 |
Advanced or Special Topics in Cancer Research: Appropriate Conduct in Science |
Mertz, Roberts |
1 / Spring |
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A review and discussion of the fundamentals of good scientific communication and ethical issuses in science.
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Nursing 802 |
Ethics and the Responsible Conduct of Research |
Ward |
1 / Spring |
Ethical issues in the design, conduct and reporting of research are examined in the context of the nature of the scientific endeavor, the structure of the research community, and professional and federal guidelines for supporting scientific integrity and controlling misconduct.
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| Chemistry/Microbiology 901 |
Seminar-Teaching of Chemistry/Advanced Seminar
|
Donohue |
1 / Fall |
The role of teaching assistant in undergraduate chemistry instruction. Effectie utilization of instructional aids. Innovaitons for better teaching.
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ADDITIONAL COURSES |
Course Department & Number |
Course Name
|
Professor |
Credits/Semester |
Pathobiologicalio/Microbiology/Medical Microbiology and Immunology 528 |
Immunology
|
Splitter
|
3 / Fall |
|
Development and functions of the immune response in animals; a comprehensive study of experimental humoral and
cellularimmunity, including a molecular basis forthese host responses.
P: Two semesters chemistry and one semester zoology or general biology
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Pathobiological/Medical Microbiology and Immunology 720 |
Advanced Immunology: Critical Thinking |
Gumperz |
3 / Fall - Odd Years |
Advanced course focusing on current questions in immunological research. Course explores immunology topics including genetic, cellular, and molecular features of immune sstem fundamental to regulation of immune responses. P: Med Micro/VetSci/Bact 528 or equiv.
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Pathobiological 675 |
Special Topics: Immunology Journal Club |
TBA
|
1-4 / Spring |
Anatomy 675
|
Topics in Anatomy
|
Svendsen, Downs
|
1-3 / Fall, Spring |
This class will cover all aspects of stem cell biology from self renewal to industrial and clinical applications. It features some of the leading experts on campus working with all types of stem cells. The format will be two one hour slots per week for each topic-the first a lecture and the second either another lecture, a discussion of papers or round table interactive sessions that will be determined by each professor.
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Anatomy 700 |
Cytoskeletal Dynamics |
Amann, Bement, Dent
|
2 / Spring |
|
Course content is topical and current. The course covers such issues as microtubule dynamics, microtubule-associated proteins, microtubule-organizing centers, actin regulatory proteins, intermediate filaments, cell motility, mitosis, process outgrowth, and cell differentiation.
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Anatomy/Animal Sciences/Physiology 725 |
Muscle Biology |
Greaser |
2 / Fall - Odd Years |
|
Anatomy, physiology, and biochemistry of muscle. Team-taught course with lecturers summarizing areas related to their current research.
P: Course in biochemistry or physical chemistry & physiology or consent of instructor.
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Biochemistry/Botany 621 |
Plant Biochemistry |
Sharkey, Bednarek
|
3 / Fall - Odd Year |
|
This course is designed for graduate students and advanced undergraduates wanting to learn biochemistry that is characteristic of plants. The course is taught in two 75-minute lectures per week. There are 2 "in-class" midterms scheduled during the semester. The final is given during the assigned final exam period and in not cumulative. A few short quantitative exercises may also be assigned in lieu of some of the points for any one exam. Grading is based on the average of all three exams.
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Biochemistry/Chemistry 665 |
Biophysical Chemistry |
Record |
4 / Fall, Spring |
Biochem 665, taught together with the advanced (honors) undergrad course Chem 565, develops the principles of solution thermodynamics and chemical kinetics, and applies this quantitative framework to discuss experimental data and analysis of the thermodynamics (driving forces, coupled conformational changes etc.) and mechanisms of biochemical processes involving proteins, lipids, and nucleic acids in solution. Applications incude protein folding, nucleic acid helix formation, michelle formation; ligand binding, cooperative binding and other assembly processes; effects of water, salt, other solutes, temperature and pressure on biochemical processes; protein-nucleic acid interactions and enzyme catalysis.
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Biochemistry 711 |
Sequence Analysis |
Palmenberg
|
2 / Fall - Even Years |
For aspiring molecular biologists and genetic engineers, designed to answer the questions: “What can you do with your sequence once you have it?” and “How can you put this information into realistic biological perspective?” Hands on laboraory course taught at actual computer terminals, designed to implement and reinforce the sequence analysis concept presented in the didactic course.
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Biomedical Engineering 601 |
Special Topics |
Radwin, Ogle, Casper, Kreeger, Alexander, Wieben |
1-3 / Fall, Spring |
Topics vary: Protein and enzyme structure and function.
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Biomolecular Chemistry 710
|
Biochemical Functions-Macromolecules |
Brow, Rayment |
2 / Spring |
This course focuses on topics and approaches applicable to an in-depth understanding of fundamental biochemical research, and is designed to provide students with a solid foundation for the research phase of their careers.
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Botany/Biochemistry/Genetics 840 |
Regulatory Mechanisms in Plant Development |
Amasino, Bleecker, Fernandez, Masson |
3 / Fall, Even Years |
Molecular mechanisms whereby endogenous and environmental regulatory factors control development; emphasis on stimulus perception and primary evens in the signal chain leading to modulated gene expression and cellular development. P: Biochemistry 501 or 601 and Botany 500 or Biocore 301 and 323.
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Botany 960 |
Seminar: Plant Physiology |
Fernandez
|
1 / Fall, Spring |
|
Different topics in plant biochemistry, molecular biology, and developmental biology each semester.
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Forest & Wildlife Ecology/Horticulture/Statistics 571 |
Statistical Methods for Bioscience I |
Ane
|
4 / Fall |
|
Descriptive statistics, distributions, one-and two-sample normal inference, power, one-way ANOVA, simple linear regression, categorical data, non-parametric methods; underlying assumptions and diagnostic work.
P: College algebra: Graduate Student or consent of instructor
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Genetics/Medical Genetics 677 |
Advanced Topics in Genetics |
Kessel, Laughon, Reiser, Pelegri, Rice |
1-3 / Fall, Spring |
Contents vary; consideration of subjects not included in the curriculum. Possible topics: advanced genetics, genetics and evolution, human genetics, contemporary issues in HIV/AIDS prevention, FAS introduction, FAS into on-line, how to facilitate social & health change, HIV/AIDS prevention advanced, gender issues & substace abuse, sexuality issues & developmental disabilities, health issues for adolescents, alcohol & related behaviors, alcohol issues: a multicultural perspective. P: For those with some background in genetics
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Genetics 875 |
Special Topics |
Masson
|
2 / Fall |
| The objective of this course is to cover the basic concepts of genetics and genomics as applied to plants. Possible topics: plant genetics, genomic and proteomic analysis. P: Genetics 466 or equivalent. |
Human Oncology 721
|
The Conduct of Science |
Clark
|
1-3 / Spring - Odd Years |
Controversial and current topics relevant to the mechanisms of specific anticancer drugs emphasizing the relation of biochemical mechanisms and molecular biology to clinical observations. Topics include: leukemias, biostatistics, DNA repair, chromatin structure and tumor pathophysiology. P: Biochem 501, 601, or cons inst.
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Medical Genetics/Oncology 707 |
Growth and Differentiation |
Ikeda, Yin
|
3 / Spring - Odd years |
|
Contemporary research issues in human biology including cancer are discussed from a genetic viewpoint. Most weeks an invited speaker gives a research lecture and associated reading material from primary literature is discussed with the course faculty and invited speaker. P: Consent of instructor or Graduate student.
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Medical Microbiology and Immunology 677 |
Advanced Topics in Medical Microbiology |
Schell |
1-3 / Fall, Spring |
Lectures on a specialized topic of current interest in medical microbiology. Course content will vary with instructor. P: Graduate Status or consent of instructor.
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Medical Microbiology and Immunology/Patho-Bio/ Microbiology 740 |
Mechanisms of Microbial Pathogenesis |
Dillard
|
3 / Fall |
The yearly course focuses on molecular mechanisms of bacterial pathogenesis and methods for studying pathogenesis. The first four weeks of the course are devoted to discussion of general principles of pathogenesis, host responses to bacteria and bacterial products, and genetic techniques for identifying virulence genes. For the remainder of the course each Tuesday session is a lecture on virulence mechanisms of a specific bacterial species, given by a researcher who is expert in that area. The Thursday sessions are made up of discussions of 2-3 papers on the specific pathogen. Student assignments include two literature critiques and an NIH-style grant proposal.
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Medical Microbiology and Immunology 773 |
Eukaryotic Microbial Pathogenesis |
Bangs and Woods
|
3 / Spring |
This yearly course focuses on cellular, molecular, and biochemical aspects of pathogenic mechanisms of eukaryotic microbial pathogens, emphasizing protozoan parasites and fungi that cause debilitating and lethal diseases in humans. These pathogens display many distinctions from bacteria and viruses in features related to pathogenesis and infection, in large part due to their phylogenetic similarity to their host organisms. Both their basic biology and ability to infect and cause disease reveal unique evolutionarily adaptations that aid our understanding of how a microbe can exploit its host, and broaden our appreciation of the diversity of eukaryotic organisms. The course is a mixture of didactic lectures covering basic mycology and parasitology, critical reading of the current literature, and student-led presentations and discussions.
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Medical Microbiology and Immunology/Biomolecular Chemistry 914 |
Seminar--Molecular Biosciences (Advanced) |
Keck
|
1 / Fall, Spring |
|
During the fall semester, molecular biosciences trainees who have not achieved dissertator status will present seminars based primarily on literature related to their projects. During the spring semester, molecular biosciences trainees with dissertator status will present seminars based upon their own research.
P: cons inst. (For MBTG Students Only)
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Oncology 675 |
Advanced or Special Topics in Cancer Research |
Mertz, Roberts
|
2 / Fall - Odd Years |
Course topics change every other year as it is offered. Contact the Oncology department for additional course information.
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Pathology 709 |
Contemporary Topics in Cell Structure and Function |
Sandor |
2 / Spring |
| In-depth introduction to current topics in cell biology. Problems and issues confronting cell biologists are explored through reading and discussion of research papers. Topic varies each year.
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Pathology 751 |
Cellular & Molecular Biology of Aging |
TBA |
3 / Fall |
Cellular and molecular pathophysiology of human disease typically afflicting the aged, such as Alzheimer's, osteoporosis, Type II diabetes and arthritis, experimental systems to study aging. P: Biochem 501 or equiv.
|
Pathology 803 |
Pathogenesis of Major Human Diseases |
Fabry |
3 / Fall |
| This course will focus on diseases that are major causes of global death and disability. Throughout the course, we will combine expert clinicians, basic scientists, and literature review on specific topics. For each major disease there will be three seminars. The first serminar will introduce the pathogenesis and current clinical treatments of major human diseases. The next serminar will focus on experimental models to study the disease pathogenesis. The last session will consist of small groups reviewing current research papers addressing disease pathogenesis and discussing the leading disease model. The course is designed for graduate students, MD or MD/PHD students and advanced undergraduates interested in pursuing a career in bench-to-bedside translation, basic and clinical research. The course will provide an opportunity to learn about research currently being conducted on specific human diseases. The major human diseases covered will include Cancer, Tuberculosis, HIV/AIDS, Malaria, Stroke, Alzheimer's Disease, Diabetes, Multiple Sclerosis, Asthma.
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Pharmacology 710
|
Cytosolic and Nuclear Signaling Mechanisms |
Tibbetts, Bresnick, Anderson |
2 / Spring - Even years |
Biochemical basis of drug action.
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Pharmacology 711 |
Neurotransmitter Receptors and Ion Channels |
Jones, Ruoho, Czajkowski
|
2 / Spring - Odd years |
A consideration of neurotransmitter receptors and ion channels from a molecular perspective. Emphasis will be on current concepts in the field. Course is directed to graduate students and outstanding senior undergraduates.
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Pharmacology 875 |
Special Topics |
Cozzi, Ruoho, Huttenlocher
|
1-3 / Spring - Odd years |
|
This course investigates the cellular and molecular signaling basis for human diseases, with a focus on cancer biology and primary immunodeficiencies. Exciting new advances in understanding molecular mechanisms of disease will be highlighted, including (but not limited to) a discussion of: Wiscott-Aldrich Syndrome and WASP protein Ataxia Telangietasia and ATM Breast Cancer and ErbB2(Her-2), Wnt, Ras, PTEN.
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Physiology/Neuroscience 610 |
Cellular and Molecular Neuroscience |
Oertel, Chiu, Banks, Czajkowski, Fettiplace |
4 / Fall |
|
Study of original papers leading to an understanding of the molecular basis of electical activity in neurons. Topics include voltage-sensitive currents, molecular biology of neuronal receptios, synaptic transmission and sensory transdution. Lectures supplemented with experiemental demonstrations and discussion sessions.
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Plant Pathology/Botany/ Entomology 505 |
Plant-Microbe Interactions: Molecular & Ecological Aspects |
German, Charkowski, Keller, Bent |
3 / Spring |
|
Uses examples from the contemporary study of plant diseases and comparisons with other host/parasite systems to explore many of the themes of modern biology. The course considers plant disease and symbioses at all levels, from molecular and genetic to ecological and integrative, with particular emphaiss on molecular biology. The course is designed for students with a sound understand of basic biology who wish to expland their knowledge to plants, plant pathogens, and their interactions with the environment. P: An upper level course in microbiology (e.g. Bact 303); Biochem (e.g. Biochem 501); and Genetics (e.g. Genetics 466) or consent of instructor.
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Neuroscience 675 |
Special Topics in Neuroscience
|
Adibhatla
|
1-3 / Fall, Spring |
|
This graduate level course will be an in-depth analysis of topics in Developmental Neuroscience with an emphasis on experimental approaches. It will be taught by a team of faculty with a diversity of expertise in the field, and will include a combination of lectures and discussions of primary literature. Possible topics covered include behavior, brain and evolution, stem cells and the central nervous system, molecular mechanisms of brain damage, reproductive endocrinology, developmental neuroscience.
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Zoology 625
|
Development of the nervous system |
Blair |
2 / Spring - Odd years |
Survey of the principles guiding neuronal development. Course will cover descriptive and experimenatal mechanisms underlying the formation of both vertebrate and invertebrate nervous systems. P: One intermed level course in biology; background in development & neurobiology recommended.
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